The cytosol, or cytoplasmic matrix, is the liquid that makes up the bulk of a cell and is the place where many different organelles sit. Glycolysis is a metabolic pathway that takes place in the cytosol and creates the energy that cells use for things like respiration. In the 1940s and onwards, scientists continued to refine the pathway and add in more details until it became what we had today. In the 1930s, Gustav Embden finally put together all the other steps that were found and created the pathway of glycolysis in full. Many scientists, like Louis Pasteur and Eduard Buchner, uncovered some of the steps in glycolysis but never connected those steps with the entire pathway. Glycolysis occurs in plant, animal, and microbe cells Preparatory phase and the energy generation phase Gustav Embden, Otto Meyerhof, and Jakub Karol ParnasĬytoplasm of prokaryotes and cytosol of eukaryotes The pathway of glycolysis took almost 100 years to decipher because the pathway includes many steps that were discovered in pieces from about 1850 to 1940s. Among those old and highly conserved processes is glycolysis. These processes play crucial roles in our survival and so they are favored by evolutionary pathways to survive. Processes like photosynthesis are also highly conserved throughout time and are similar in many different plants and cyanobacteria. Where does the Kreb’s cycle take place? It occurs both within the mitochondrial matrix of eukaryotic cells and also in the cytoplasm of prokaryotic cells. But first, glycolysis takes place in the cytoplasm of a cell.

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